Matrixyl (Palmitoyl Pentapeptide‑4) is a trademarked cosmetic peptide developed by Sederma/Croda, designed to stimulate collagen and elastin synthesis, reduce wrinkles, and improve skin firmness. It is available in several commercial configurations such as Matrixyl®, Matrixyl® 3000, Matrixyl® Synthe’6, and Matrixyl® Morphomics®.

KEY FEATURES 

Collagen stimulation: Boosts synthesis of collagen types I, III, and IV by up to 350% in vitro.

Fibronectin & elastin: Increases production by up to 200%, improving elasticity.

Wrinkle reduction: Clinical studies show visible decreases in wrinkle depth and fine lines.

Skin repair: Supports wound healing and dermal regeneration.

Non‑irritating: Gentler than retinoids, compatible with other actives.

TECHNICAL SPECIFICATIONS 

INCI Name (original Matrixyl): Palmitoyl Pentapeptide‑4 (Pal‑KTTKS).

Sequence: Lys‑Thr‑Thr‑Lys‑Ser (KTTKS) with palmitoyl fatty acid chain for enhanced penetration.

Molecular Weight: ~805 Da 

Form: Cosmetic grade peptide, ≥95% purity, typically supplied as powder or solution 

Solubility: Water‑soluble when formulated with carriers.

Recommended Concentration: 3–5% in topical formulations (serums, creams, lotions) 

Application Protocol: Twice daily; results visible after 4–8 weeks

Storage: 4–7 °C, stable for 24 months (Matrixyl 3000) 

AVALAIBLE CONFIGURATION 

Matrixyl® (original) — Palmitoyl Pentapeptide‑4. This was the first generation peptide, proven to stimulate collagen types I, III, and IV, reduce wrinkles, and improve skin firmness.

Matrixyl® 3000 — A blend of Palmitoyl Tripeptide‑1 and Palmitoyl Tetrapeptide‑7. It enhances collagen and elastin production while also reducing inflammation, making it one of the most widely used versions in serums.

Matrixyl® Synthe’6 — Palmitoyl Tripeptide‑38. This variant targets dermal matrix repair, filling deeper wrinkles and stimulating multiple structural proteins including collagen, fibronectin, and hyaluronic acid.

Matrixyl® Morphomics® — A newer proprietary peptide complex. It focuses on sagging and facial contours, marketed as a solution for “morphological” signs of aging.

Matrixyl® Inside — A branding initiative used by skincare companies to certify that their products contain genuine Croda Matrixyl peptides.