Palmitoyl pentapeptide-4 to palmitoyl hexapeptide-12 (often associated with the Matrixyl series) are synthetic messenger peptides designed for advanced dermatological research. By attaching a palmitoyl (fatty acid) group to specific amino acid chains, these molecules achieve superior skin penetration and stability compared to standard peptides.

1. Palmitoyl Pentapeptide-4 (Matrixyl)

Known as "micro-collagen," this 5-amino acid peptide is a precursor to collagen type I.

• Mechanism of Action: It signals fibroblast cells to synthesize essential extracellular matrix (ECM) proteins, including collagen (types I, III, and IV), elastin, and hyaluronic acid.
  
  
• Research Indications: Extensively studied for reducing wrinkle depth, improving skin roughness, and supporting wound healing.
  
  
• Technical Data:
  
  
• CAS Number: 214047-00-4
  
  
• Molecular Weight: ~802.07 g/mol

2. Palmitoyl Tetrapeptide-7

Often combined with other peptides to address the inflammatory aspects of aging.

• Mechanism of Action: It works by suppressing the production of excess pro-inflammatory cytokines, specifically interleukin-6 (IL-6), which can lead to skin sensitivity and degradation.
  
  
• Research Indications: Studied for its ability to reduce redness, puffiness, and environmental damage by stabilizing the skin's defense systems.
  
  
• Technical Data:
  
  
• CAS Number: 221227-05-0
  
  
• Molecular Weight: ~694.92 g/mol

3. Palmitoyl Hexapeptide-12

Formerly known as palmitoyl oligopeptide, this sequence (Gly-His-Lys) mimics the fragments of elastin.

• Mechanism of Action: It functions as a signal peptide, "telling" the skin to look firmer by influencing key supportive elements in the uppermost epidermal layers.
  
  
• Research Indications: Research focuses on its ability to strengthen the skin barrier, improve moisture retention, and minimize the appearance of deep wrinkles.
  
  
• Technical Data: Found effective in research concentrations as low as parts per million.
  
  

Technical & Logistics Data