Epithalon (Epitalon, AEDG tetrapeptide) is a synthetic pineal peptide studied for telomerase activation, melatonin regulation, and geroprotective effects. It is supplied as a research-only compound, typically in 10 mg lyophilized vials at ≥98% purity.

KEY FEATURES 

Molecular Identity: Tetrapeptide sequence Ala-Glu-Asp-Gly (AEDG).

Primary Mechanism: Activates telomerase, lengthening telomeres and potentially slowing cellular aging.

Secondary Actions:

Regulates melatonin synthesis and circadian rhythm.

Exhibits antioxidant, neuroprotective, and antimutagenic properties.

Modulates immune activity (IL-2 expression, thymocyte mitogenic activity).

Research outcomes:

Animal studies show lifespan extension.

TECHNICAL SPECIFICATIONS 

Full Name: Epithalon / Epitalon / Epithalone

CAS Registry Number: 307297-39-8

Molecular Weight: 390.35 g/mol

Residues: 4 (tetrapeptide)

Sequence: H-Ala-Glu-Asp-Gly-OH

Classification: Khavinson bioregulatory peptide (pineal gland regulator)

Appearance: White to off-white lyophilized powder

Purity: ≥98% (HPLC/MS verified)

Solubility: Freely soluble in bacteriostatic water

Stability: Highly stable in lyophilized and reconstituted forms

Storage:

Lyophilized: –20 °C, protected from light

Reconstituted: 4 °C, protected from light 

AVAILABLE CONFIGURATIONS :

Standard Research Format:

10 mg vial (lyophilized powder, ≥98% purity)

Supplied with batch-specific COA (HPLC, LC-MS, microbial screening)

Packaging: Tamper-evident sealed vials, research-grade labeling.

Diluent Recommendation: Bacteriostatic water for reconstitution.

Supplier Variations: Some labs may offer different vial sizes (e.g., 5 mg, 20 mg), but 10 mg ≥98% purity is the most common model.