Survodutide (BI 456906) is a novel dual agonist of the glucagon-like peptide-1 (GLP-1) and glucagon (GCGR)receptors. Its key features center on its ability to simultaneously target appetite and liver function for metabolic improvements.

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Clinical & Therapeutic Features

• Significant Weight Loss: In Phase III SYNCHRONIZE-1 trials, participants without type 2 diabetes achieved an average body weight reduction of up to 16.6% over 76 weeks.
  
  
• Dual Mechanism of Action: It combines GLP-1 agonism, which reduces appetite and increases satiety, with glucagon agonism, which directly acts on the liver to enhance energy expenditure and fat metabolism.
  
  
• Metabolic Health Marker Improvement: Treatment has led to significant reductions in waist circumference, a key indicator of visceral fat and cardiometabolic risk.
  
  
• Liver Disease Targeting: Because it activates glucagon receptors in the liver, it is being studied for its ability to reduce hepatic fat, resolve inflammation, and improve fibrosis in patients with MASH (Metabolic Dysfunction-Associated Steatohepatitis).
  
  
• Long-Acting Profile: It has a plasma half-life of approximately 6 days, supported by a high binding affinity to human serum albumin (>99%), allowing for once-weekly dosing.

Technical Overview

• Mechanism of Action: It acts as a unimolecular dual agonist that simultaneously activates GLP-1 receptors to reduce food intake and improve glucose tolerance, while activating glucagon receptors to increase energy expenditure and promote fat metabolism in the liver.
  
  
• Structure: A 29-amino-acid linear synthetic peptide acylated with a C18 fatty diacid moiety. This acylation enables high binding affinity to human serum albumin (>99%), extending its plasma half-life to approximately 6 days for once-weekly dosing.
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• Potency (EC50): In CHO-K1 cell assays, its functional potency is approximately 0.33 nM for the GLP-1 receptor and 0.52 nM for the glucagon receptor.
  
  

Technical Specifications

Logistics & Customs Data

• HS / Custom Code: 2937.19.00. This code covers polypeptide and protein hormones, their derivatives, and structural analogues.
  
  
• Regulatory Category: Typically classified as a Laboratory Reagent or for Research Use Only (RUO) to facilitate international shipping for laboratory studies.