Sermorelin acetate is a synthetic peptide (GRF 1‑29 NH₂) that mimics the first 29 amino acids of natural growth hormone–releasing hormone (GHRH). It is supplied as a lyophilized powder for reconstitution, with purity ≥ 98–99% by HPLC, and is available in multiple vial strengths for subcutaneous injection.

KEY FEATURES 

Peptide Class: GHRH analog (shortest fully functional fragment of native GHRH).

Mechanism: Stimulates pituitary somatotrophs via GHRH receptor → triggers cAMP/PKA signaling → pulsatile GH release.

Physiological Advantage: Preserves natural feedback regulation by somatostatin, reducing risk of GH overdose compared to recombinant GH.

Therapeutic Use: Diagnostic agent for pituitary function; treatment of pediatric growth hormone deficiency.

Research Use: Endocrinology, peptide therapy studies, and drug development.

TECHNICAL SPECIFICATIONS 

Chemical Name: Sermorelin acetate

CAS Number: 86168‑78‑7

Molecular Formula: C₁₅₁H₂₅₀N₄₄O₄₄S

Molecular Weight: ~3,358–3,418 Da (depending on salt form) 

Sequence

H‑Tyr‑Ala‑Asp‑Ala‑Ile‑Phe‑Thr‑Asn‑Ser‑Tyr‑Arg‑Lys‑Val‑Leu‑Gly‑Gln‑Leu‑Ser‑Ala‑Arg‑Lys‑Leu‑Leu‑Gln‑Asp‑Ile‑Met‑Ser‑Arg‑NH₂

Purity: ≥ 98–99% (HPLC assay) 

Appearance: White/off‑white lyophilized powder

Storage: −20 °C; ship on wet ice 

Packaging: Sterile vials, sealed under nitrogen, supplied for reconstitution with bacteriostatic water.

AVAILABLE CONFIGURATIONS 

Vial Strengths: Commonly 0.5 mg, 1 mg, 2 mg (generic/compounded supply)

Formulation: Lyophilized powder for subcutaneous injection

Bulk Supply: Available for laboratory and wholesale catalog orders (custom batch sizes possible) 

Quality Standards: Manufactured under cGMP with validated solid‑phase peptide synthesis (Fmoc chemistry), purified and lyophilized with > 98% sequence integrity