SLU-PP-332 is a synthetic small molecule and non-toxic pan-agonist targeting estrogen-related receptors (ERRs), with the highest potency for ERRα. It is widely categorized as an exercise mimetic because it replicates many of the metabolic and structural effects of physical activity at the cellular level without requiring intense physical exertion.

1. Molecular Profile

• IUPAC Name: 4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide.

   

   

• Chemical Formula: C18​H14​N2​O2​.

   

   

• Molecular Weight: Approximately 290.32 g/mol.

   

   

• CAS Number: 303760-60-3.

   

   

• Physical Form: Typically a white to beige/yellow solid powder.

   

   

2. Mechanism of Action

SLU-PP-332 activates the ERR system, which acts as a master regulator of energy metabolism:

• ERR Agonism: It binds to all three ERRs (α,β,γ) but shows the highest affinity for ERRα (EC50 = 98 nM).

• Mitochondrial Biogenesis: It upregulates transcription of genes involved in mitochondrial function, ATP production, and cellular respiration.

   

   

• Metabolic Shift: It encourages the body to use fat as fuel by increasing fatty acid oxidation and shifting energy use toward lipids rather than just carbohydrates.

   

   

• Muscle Fiber Transition: In animal models, it has been shown to increase type IIa oxidative skeletal muscle fibers, which are essential for enhanced exercise endurance.

   

   

3. Research Indications

• Exercise Endurance: Studies in mice show a significant increase in running distance and time after administration.

   

   

• Weight Management: It has demonstrated the ability to reduce fat mass accumulation and counteract metabolic syndrome in obese models, even without changes in food intake.

   

   

• Cardioprotective Properties: Early research suggests it may improve cardiac contractility and reduce fibrosis in heart failure models.

   

   

• Insulin Sensitivity: It shows potential for improving glucose tolerance and lowering fasting insulin, which may be relevant for type 2 diabetes research.

   

   

4. Technical Specifications & Logistics

• Purity: Typically ≥98% as verified by HPLC.

   

   

• Solubility: Soluble in DMSO (2 mg/mL, warmed); practically insoluble in water.

   

   

• Storage: Long-term storage at -20°C in a dry, dark environment; short-term storage (weeks) at 2-8°C.

   

   

• HS Code: 2933.99.00 (Heterocyclic compounds; other).

   

   

• UNSPSC Code: 51111800.

  Medical Caution: SLU-PP-332 is strictly for research and laboratory use only. It is not intended for human consumption or for the treatment of any medical condition. Always consult a licensed medical professional for advice on metabolic health or exercise programs.