Somatropin is a recombinant human growth hormone (HGH) used in medicine for growth hormone deficiency and related conditions. It is a 191‑amino acid protein identical to natural pituitary HGH, produced via recombinant DNA technology. It is supplied as sterile lyophilized powder or prefilled cartridges for subcutaneous injection, with multiple dosing strengths and delivery systems.

KEY FEATURES 

Biological Identity: Recombinant human growth hormone, 191 amino acids, ~22,125 Da molecular weight.

Production: Synthesized in E. coli or yeast (Saccharomyces cerevisiae) using recombinant DNA technology.

Activity: Stimulates tissue growth, skeletal development, protein synthesis, and metabolism regulation via IGF‑1.

Therapeutic Use: Pediatric growth failure, Turner syndrome, Prader‑Willi syndrome, adult GH deficiency, HIV wasting, short bowel syndrome.

Administration: Subcutaneous injection, daily or weekly depending on formulation.

TECHNICAL SPECIFICATIONS 

Formulation: Lyophilized powder or prefilled cartridge; reconstituted with sterile diluent.

Concentration: Typically 10 mg/mL after reconstitution (varies by brand).

Stability: Oxygen‑sensitive; requires refrigeration (2–8 °C). Avoid repeated freeze‑thaw cycles.

Labeling Convention: 1 mg somatropin ≈ 3 IU biological activity.

Purity Standards: 89–105% of labeled content; impurities ≤10% total; endotoxins <5 IU/mg. 

AVAILABLE CONFIGURATIONS 

Humatrope – 5 mg vials (15 IU), 6 mg, 12 mg, 24 mg cartridges – supplied as vials with diluent or cartridges for pen injectors

Genotropin – 5 mg and 12 mg cartridges, MiniQuick single‑dose pens (0.2–2 mg) – flexible pediatric dosing options

Norditropin – 5–30 mg FlexPro pens – prefilled, ready‑to‑use, limited room‑temperature stability

Omnitrope – 5.8 mg vials or cartridges – biosimilar HGH, compatible with pen devices

Saizen / Zomacton – 4–10 mg vials – supplied with diluent for reconstitution

Somatropin Biopartners – 2 mg prolonged‑release suspension – weekly injection, yeast‑derived formulation

Skytrofa (lonapegsomatropin) – sustained‑release weekly injection – prefilled device for extended dosing interval