IGF-1 (Insulin-like Growth Factor 1) is a recombinant peptide hormone with a molecular weight of ~7.5–9.1 kDa, supplied in lyophilized powder or solution formats, and available in both native and analog configurations (e.g., Long R3 IGF-1). It is cataloged under metabolic/endocrine peptides and used in growth, repair, and cell culture research.

KEY FEATURES 

Biological Role: Mediates growth hormone effects, stimulates cell proliferation, differentiation, and tissue repair.

Potency: Effective at very low concentrations (ED50 ≤ 2–10 ng/mL depending on variant).

Applications: Muscle, bone, cartilage research; serum-free cell culture supplement; metabolic and anti-aging studies.

Variants: Native IGF-1 and recombinant analogs (e.g., Long R3 IGF-1 with enhanced stability and potency).

TECHNICAL SPECIFICATIONS 

Sequence: 70 amino acids (native IGF-1)

Molecular Weight: ~7.5 kDa (native), ~9.1 kDa (Long R3 IGF-1)

Expression System: Recombinant production in E. coli

Purity: ≥98% confirmed by SDS-PAGE and HPLC

Activity: ED50 ≤ 2 ng/mL (native IGF-1 cell proliferation assay); ED50 ≤ 10 ng/mL (Long R3 IGF-1 protein synthesis assay)

Form: Lyophilized powder, carrier-free or lyophilized from 0.1 M acetic acid

Storage: -20°C long-term; reconstituted solution stable for 1 week at 2–8°C; stock solutions stable up to 3 months at -20°C/-70°C

CAS Number: 67763-96-6

AVAILABLE CONFIGURATIONS 

Lyophilized powder vials: 100 µg, 1 mg, 2 mg, 5 mg (research-grade).

Reconstituted solutions: Vendor-specific, short-term stability.

Bulk peptide supply: ≥100 mg for extended laboratory use.

Analog models: Long R3 IGF-1 (enhanced potency, reduced binding to IGFBPs).