AICAR (Acadesine) is a synthetic nucleoside analog, cataloged as a research compound only. Its key features include AMPK activation, exercise‑mimetic effects, and metabolic regulation. Technical specifications highlight its chemical identity, solubility, and storage conditions, while available configurations are typically small‑scale RUO vials (1 mg, 5 mg, 10 mg).

KEY FEATURES 

AMPK Activator: Mimics AMP via conversion to ZMP, triggering energy‑conserving pathways.

Metabolic Effects: Enhances glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.

Exercise Mimetic: Produces endurance‑like adaptations in muscle without physical exertion.

Research Applications: Studied in diabetes, ischemia, cancer metabolism, and exercise physiology.

Regulatory Status: Not FDA‑approved; banned in professional sports (WADA list).

TECHNICAL SPECIFICATIONS 

Chemical Name – 5‑Aminoimidazole‑4‑carboxamide ribonucleoside (AICAR, Acadesine)

CAS Number – 2627‑69‑2

Molecular Formula – C₉H₁₄N₄O₅

Molecular Weight – ~258.23 g/mol

Purity – ≥98% (research‑grade)

Solubility – DMSO: 52–116 mg/mL; Water: 52–65 mg/mL; Ethanol: insoluble

Storage – Powder: −20°C (stable 3 years); Solution: −80°C (stable 2 years)

Pathways Targeted – AMPK, Autophagy, Mitophagy, PI3K/Akt/mTOR, YAP signaling

Biological Activity – Induces apoptosis in B‑CLL cells (EC₅₀ ~380 μM); inhibits fatty acid & sterol synthesis in hepatocytes

AVAILABLE CONFIGURATION 

Standard RUO Vials: 1 mg, 5 mg, 10 mg (powder form).

Bulk Orders: Larger quantities available upon request for institutional labs.

Catalog Codes:

MedChemExpress: HY‑13417

Selleckchem: S1802

Cayman Chemical: 10010241

Tocris: 2840