SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide modeled after the N-terminal end of SNAP-25, a key protein in the SNARE neurotransmitter release complex. It is primarily investigated in biochemical assays for its interactions with SNARE complex proteins and neurotransmitter release mechanisms.

Key Features

• Mechanism of Action: SNAP-8 functions as a competitive analog for SNAP-25 binding within the SNARE complex. This disruption can modulate vesicular fusion and neurotransmitter exocytosis at the neuromuscular junction in research models.
• Comparison to Argireline: SNAP-8 is an analogue of Argireline (Acetyl Hexapeptide-8) that extends the sequence by two additional amino acids, which may enhance its competition within the SNARE complex.
• Purity: Research-grade preparations typically feature a purity level of ≥99%, confirmed by HPLC and Mass Spectrometry.

Technical Specifications

• Molecular Weight: Approximately 901.0 g/mol.
• Molecular Formula: C₄₁H₆₀N₁₀O₁₄.
• Sequence: Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂.
• CAS Number: 868844-74-0.
• Appearance: Typically supplied as a lyophilized white powder.

Available Configurations & Pricing (2026)

Storage and Handling

• Long-term (Lyophilized): Store at -20°C or below 8°C in a dry environment to maintain research viability for up to 12–18 months.
• Post-reconstitution: Refrigerate at 2–8°C and use within 21–30 days. Avoid repeated freeze-thaw cycles.